2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-165099A
    C-8 Ceramide-1-phosphate ammonium 474943-70-9 98%
    C-8 Ceramide-1-phosphate (ammonium) is a ceramide.
    C-8 Ceramide-1-phosphate ammonium
  • HY-165641S
    N-Octadecanoyl-sulfatide-d3 2699608-06-3 98%
    N-Octadecanoyl-sulfatide-d3 is deuterium labeled N-Octadecanoyl-sulfatide. N-Octadecanoyl-sulfatide is an ester product.
    N-Octadecanoyl-sulfatide-d3
  • HY-165708A
    (Z)-Nonadec-7-en-1-ol 2692623-27-9 98%
    (Z)-Nonadec-7-en-1-ol ((7Z)-7-Nonadecen-1-ol) is an ester product.
    (Z)-Nonadec-7-en-1-ol
  • HY-165765A
    8(R)-Hydroxyoctadecanoic acid 1212331-85-5 98%
    8(R)-Hydroxyoctadecanoic acid is an ester product.
    8(R)-Hydroxyoctadecanoic acid
  • HY-165869A
    Cholesteryl 11(Z)-vaccenate 13110-26-4 98%
    Cholesteryl 11(Z)-vaccenate (Cholesterol 11Z-octadecenoic acid ester) is an ester product.
    Cholesteryl 11(Z)-vaccenate
  • HY-165875A
    13(S)-HODE Cholesteryl ester 141554-21-4 98%
    13(S)-HODE Cholesteryl ester is an ester product.
    13(S)-HODE Cholesteryl ester
  • HY-166001A
    Methyl 10(S),11(S)-epoxy-9(S)-hydroxy-12(Z)-octadecenoate 135357-33-4 98%
    Methyl 10(S),11(S)-epoxy-9(S)-hydroxy-12(Z)-octadecenoate is an ester product.
    Methyl 10(S),11(S)-epoxy-9(S)-hydroxy-12(Z)-octadecenoate
  • HY-166214A
    Ethyl 7(Z)-nonadecenoate 2692622-83-4 98%
    Ethyl 7(Z)-nonadecenoate is an ester product.
    Ethyl 7(Z)-nonadecenoate
  • HY-166315S
    C15-Ceramide-d7 99%
    C15-Ceramide-d7 is deuterium labeled C15-Ceramide. C15-Ceramide is an ester product.
    C15-Ceramide-d7
  • HY-166478S
    O-Desmethyl carvedilol-d5 1794817-24-5 98%
    O-Desmethyl carvedilol-d5 (Desmethylcarvedilol-d5) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 μg/kg, respectively).
    O-Desmethyl carvedilol-d5
  • HY-166548S
    Remogliflozin etabonate-d7 1233515-93-9
    Remogliflozin etabonate-d7 (GSK189075-d7) is the deuterium labeled Remogliflozin etabonate. Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models.
    Remogliflozin etabonate-d7
  • HY-17386AR
    Rosiglitazone hydrochloride (Standard) 302543-62-0 98%
    Rosiglitazone (hydrochloride) (Standard) is the analytical standard of Rosiglitazone (hydrochloride). This product is intended for research and analytical applications. Rosiglitazone (BRL 49653) hydrochloride is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone hydrochloride is a TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone hydrochloride can be used in the research of obesity and diabetes, senescence, ovarian cancer.
    Rosiglitazone hydrochloride (Standard)
  • HY-17437AR
    Mefloquine hydrochloride (Standard) 51773-92-3 98%
    Mefloquine (hydrochloride) (Standard) is the analytical standard of Mefloquine (hydrochloride). This product is intended for research and analytical applications. Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research.
    Mefloquine hydrochloride (Standard)
  • HY-17504BR
    Rosuvastatin Sodium (Standard) 147098-18-8 98%
    Rosuvastatin (Sodium) (Standard) is the analytical standard of Rosuvastatin (Sodium). This product is intended for research and analytical applications. Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
    Rosuvastatin Sodium (Standard)
  • HY-176999S
    EOTMBA-d3
    EOTMBA-d3 is the deuterium labeled EOTMBA (HY-176999). EOTMBA is a peptide labeling reagent and can be used for quantitative analysis of dipeptides and tripeptides.
    EOTMBA-d3
  • HY-179747A
    20:0(2S-OH) Ceramide 1246298-48-5 98%
    20:0(2S-OH) Ceramide is a ceramide.
    20:0(2S-OH) Ceramide
  • HY-179763A
    17:0 (2S-OH)-Ceramide 1246298-47-4 98%
    17:0 (2S-OH)-Ceramide is a ceramide.
    17:0 (2S-OH)-Ceramide
  • HY-179780A
    18:0(2S-OH) Ceramide 34839-04-8 98%
    18:0(2S-OH) Ceramide is a ceramide.
    18:0(2S-OH) Ceramide
  • HY-179783A
    18:0 Dibromo MG (S-isomer) 2260670-18-4 98%
    18:0 Dibromo MG (S-isomer) acts as a detergent for crystallization.
    18:0 Dibromo MG (S-isomer)
  • HY-179786A
    18:1 (2S-OH) Ceramide 1246298-53-2 98%
    18:1 (2S-OH) Ceramide is a ceramide.
    18:1 (2S-OH) Ceramide
Cat. No. Product Name / Synonyms Application Reactivity